The following conditions are highly prevalent in people with MASLD, as established by research. You are at risk of MASLD if you have any of the following conditions.
Risk Factors
MASLD
ARE YOU AT THE RISK OF MASLD AND MASH?
HIGH CALORIE FOOD INTAKE WITH SEDENTARY LIFESTYLE
If your daily diet includes a high intake of calorie-rich foods containing sugars, fats, and carbohydrates, and you sit for long hours without any physical exercise into your routine, then you are at high risk of MASLD (Metabolic dysfunction-Associated Steatotic Liver Disease).
OVERWEIGHT, OBESE AND SEVERELY OBESE
Being overweight or obese especially excess weight around the tummy area (central obesity) will put you at the risk of MASLD. More than 95% of the severely obese people undergoing bariatric surgery for reducing weight are known to have MASLD.
INSULIN RESISTANCE (IR)
IR is a condition where the cells do not respond to insulin hormone, which is required for the uptake and utilization of glucose (sugar) from blood for energy production
METABOLIC SYNDROME OR ONE OR MORE OF THE TRAITS OF METABOLIC SYNDROME
Not just metabolic syndrome, even a single feature of metabolic syndrome can raise your risk of MASLD. Metabolic syndrome is a group of disease characteristics linked to overweight and obesity.
The presence of any three or more of the following features can be considered metabolic syndrome.
TYPE 2 DIABETES
If you are a type 2 diabetic, chances are high that you may have MASLD. In one study, it was found that nearly ⅓ to ⅔ of patients with type 2 diabetes have MASLD. It is a well-established fact that type 2 diabetes and MASLD are so interlinked that both can develop almost simultaneously.
DYSLIPIDEMIA/ HIGH OR ABNORMAL LEVELS OF FATS IN THE BLOOD
“Dys” means abnormal, “lipid” means fat and “emia” means in the blood. High levels of triglycerides (a type of fat) and abnormal levels of cholesterol, with high total cholesterol, high LDL or low HDL cholesterol all contribute to risk of MASLD. Studies have shown that more than 50% of patients with dyslipidemia have MASLD.
INCREASING AGE
With advancing age the risk of developing MASLD increases
GENDER
It is believed that males have two times higher risk of MASLD than females
OTHER CONDITIONS THAT CAN PUT YOU AT THE RISK OF MASLD
- Hormonal disorders – Disorders of hormones like Hypothyroidism (underactive thyroid gland), PCOD – Polycystic Ovarian Syndrome that is independent of obesity and hypopituitarism (underactive pituitary gland)
- Obstructive sleep apnea – Interruption of sleep due to constant obstruction of airway during sleep making the person to wake up very often
- Psoriasis – An autoimmune disease of the skin characterized by patches of abnormal skin that produces plaques of thickened patches that are typically red, itchy, and scaly
- Hypertension – High blood pressure
- Osteoporosis – A condition in which bones become weak and brittle due loss of bone minerals
- Colorectal cancer – A cancer of the colon or rectum, located at the digestive tract’s lower end
- Pancreatoduodenal resection – A surgery where part of the pancreas (gland producing insulin) along with other parts of the digestive system like duodenum (part of intestine), gall bladder, etc. are removed for the treatment purpose like cancers or injuries to the said organs
Reference:
Chalasani, N. , Younossi, Z. , Lavine, J. E., Charlton, M. , Cusi, K. , Rinella, M. , Harrison, S. A., Brunt, E. M. and Sanyal, A. J. (2018), The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases. Hepatology, 67: 328-357. doi:10.1002/hep.29367
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